uav;rsm; ESifh tqdyfaphwrsKd;
þ&mpk ESpfydkif;wGif &efukefNrdKYwGif;&Sd tqdyfoifh vlem vufcH&m Xmersm;odkY enf;rsKd;pHkjzifh tqdyf oifhcH&aom vlemrsm; tcsdeftcg ra&G;a&muf&Sd vmwwfMuNyD; ¤if;wdkY\ ta&twGuf rSmvnf; waeYwjcm; wdk;yGm;vsuf &Sdonfudk awGY&avonf/ taBumif; trsdK;rsdK;aBumifY tqdyfoifYí a&muf&SdvmBuaom vlemrsm;rSm trsm;tm;jzifY vlrIa&;? pD;yGm;a&;? ynma&; tqifrajy jzpfaomaBumifY pdwfnpfí vkyfrdvkyf&mudk jyKrd&mrS a&muf&SdvmBujcif;jzpfonf/ ¤if;wdkY oHk;pGJaom ypönf;rsm;rSmvnf; acsmif;qdk; aysmufaq;? tdyfaq;? ESvHk;aq;? tzsm;aysmufaq;ponfY aq;0g;rsm;rSpí a&eHqD? "gwfqD? t&ufysH? aBuG*sD;cGßwfaq;? ydkvdk*sydk;owfaq; txd &SdBuavonf/
tqdyfoifh olrsm;\ wlnDaomtcsufum; w'*FtwGif;jzpfay:aom pdwfzdpD;rIudk rcHedkifí aomufoHk;rdBujcif; jzpfonf/
,ckESpfrsm;wGifrl wrlxl;jcm;pGmjzifY a&muf&SdvmBuaom tqdyfoifUvlemrsm;rSm uav;i,frsm; jzpfBujyD; ¤if;wdkYrSm pdwfnpfí tqdyfoifYvlem jzpf&jcif;rsKd;r[kwfay/ uav;i,frsm; twwfprf;um pm;oHk;Buaom t&mrSm jcHpnf;&dk; Buufqlyif½dkif;[k vltrsm;odBuaom tyifrS&aom Buufqlaph jzpfonf/ Muufqludk jrefrmtbd"mef tusOf;csKyf twJG (1) pmrsufESm (60) wGif taphrS&aom qDudk 0rf;EIwfqD tjzpfoHk;&aom vufjcm;&GufBuD;&Sdonfh tyif [kazmfjycJhonf/
Muufql trsdK;aygif; 70 ausmf&Sdonfhteuf Muufqlyif½dkif;\ rsKd;&if;trnfrSm Euphorbiaceae jzpfjyD; &ku©aA'trnfrSm jatropa curcus jzpfonf/
MuufqlyifESifh tyifxGuf ypönf;rsm;udk wcsKdYaom tmz&du taemufydkif; a'orsm;wGif 0rf;EIwfaq;? oHcsaq; tjzpfvnfaumif;? arG;zGm;& vG,fulap&ef vnf;aumif;? om;avsmapjcif; tvdkYiSm vnf;aumif;? a&zsif;pJGa&m*g? a*gufa&m*g? wcsKdYaom ta&jym; a&m*grsm;udk uko&ef vnf;aumif; oHk;pJGonfudk awGU&onf/
NcHpnf;½dk; Muufql½dkif; tapYudk Budwfí&aomqDudk v,f,mvkyfief;oHk; vufwGef; xGefpufESifh a&pkyfpuf? 'DZ,ftif*sifrsm;wGif jyefvnfjyKjyif&ef rvdkyJ wdkuf&dkufxnfhoGif; toHk;jyKedkifonf/
jrefrmEdkifiH tESHtjym;wGif Buufqlyif&dkif;rsm;udk vGefcJYaomwpfESpfcefYu pwif pdkufysdK;cJYaomfvnf; Buufqlyifonf 6 vrS 8 vwGif pwifí toD;poD;ekdifaomtyif jzpfav&m ,ckvdk aEG&moD ausmif;tm;&ufwGif &yfuGufwdkif;&Sd BuufqlyifwdkYü toD;rsm; a0a0qmqm jzpfaeBujcif; jzpfonf/
BuufqloD; wvHk;wGif tapY 3 apY yg0ifonf/ tapY wapYpDudk tcHGyg; teufa&mif? tndka&mif uav;rsm;jzifY tkyfxm;jyD; twGif;ü tjzLa&mif&SdonfY BuufqlapY twGif;om; &Sdonf/ ¤if;tjzLa&mif twGif;om;\ t&omrSm Am'HapY? oD[dkapYwdkYuJYodkY uGßwfqwfí qdrfYaomaBumifY uav;rsm; prf;oyf pm;oHk;rdBujcif;? BudKufESpfoufí xyfrHpm;oHk;rdjcif; jzpfonf/
trSefppfppfwGif BuufqlapYwGifyg0ifaom "gwfwrsKd;onf qdkuf&mEdkuf tqdyfxuf tqaygif; 6000? cavmuf ajrGqdyfxuf tqaygif; 10000? ydkrdkjyif;xefjyD; obm0 twdkif; awGY&Sdedkifaom tqdyfwrsdK; jzpfonf/
BuufqlwGif t"dutm;jzifY tqdyfjzpfapaomt&m ESpfrsdK;yg0ifonf/ wrsdK;rSm &Dpif (ricin) jzpfjyD; aemufwrsdK;rSm RCA (Ricinus communis agglutinin) jzpfonf/ odkYaomf BuufqlapYudk pm;oHk;jcif;rS &&Sdaom tqdyfoifY vu©Pmrsm;onf &Dqif\ tmedoifaBumifYom jzpfavonf/
xkdodkYjzpf&jcif;rSm RCA udk tleH&Hrsm;rS rpkyf,ledkifaomaBumifY jzpfonf/ tu,fírsm; RCA udk aoG;aBumxJodkY wdkuf½dkufxdk;oGif;rdygrl ¤if;onf aoG;eDOrsm;pGmudk aygufuJGapjcif;jzifh vlom;wdkYtm; tEÅ&m,fjyKEdkifayonf/ tqdyfoifYcH&aom uav;i,fonf BuufqlapY\ tjyifvTm trJudkcGmjyD; twGif;om;udk 0g;pm;rdaomtcsdefü Ricin tmedoifrsm; pwifjzpfay:apNyD;? tqdkyg Ricin onf cE¨mudk,fwGif;&SdqJvf (cells) rsm;udk tqdyfoifh apaomaMumifhjzpfonf/
NcHpnf;½dk;Muufql½dkif;\ taphjzpfaom MuufqlaphwGifyg0ifaom y&dkwdef; (protein) wrsKd;jzpfonfh umpif (carcin) onfvnf; &Dpif (Ricin) uJhodkYyif tpGrf; tmedoif&SdNyD; jyif;tm; tenf;i,f avsmhavonf/
Muufqlaphudk pm;oHk;rdaom olonf pm;jyD;em&D0ufrS 1 em&DtwGif; vnfacsmif; yljcif;? Adkuf&pfemjcif; rsm;cHpm;&NyD; xdkYaemufrl;jcif;? tefjcif;? 0rf;oGm;jcif;rsm; jzpfekdifygonf/ pm;oHk;aom yrmPrsm;onfESifh trSs aoG;0rf;oGm;jcif;? aoG;tefjcif;? a&"gwf tvGeftrif; qHk;½IH;jcif;\ vu©Pmrsm;jzpfaom aoG;aygifusjcif;? ESvHk;ckefjrefjcif;? a&iwfjcif;? tmacgifajcmufjcif;? qD;enf;jcif; odkYr[kwf qD;rxGufedkifawmhjcif;? rsufwGif; csKdifh0ifjcif;? uav;i,frsm;wGif ta&jym;\ elasticity avsmh&JoGm;jcif; wdkYudk awGY&wwfonf/
xdkYtjyifacGß;xGufjcif;? rsufqHusOf;jcif;? touf½Ijrefjcif;? Ekef;jcif;? MuGufwufjcif;ESifh yifrtm½HkaMum pepf tm;enf;jcif;wdkY jzpfwwfayonf/
umpif (carcin) onfvnf; cE¨mukd,fwGif;&Sd aoG;eDOrsm;udk aygufuJG apaomaMumifh rsufvHk;wGif; aoG;,dkpdrfhjcif;? aoG;0rf;oGm;jcif;? aoG;tefjcif;? tonf;ESihf ausmufuyfudk xdcdkufapjcif; wdkYudkyg jzpfapwwfonf/ NcHpnf;&dk; Muufqlyif&dkif;\ yifpnf? t&Guf? toD;wdkYwGifvnf; tvm;wl tmedoifrsm; &SdaMumif; awGY&Sd&ao;onf/
tqdyfoifhaom olonf tcsdefwdktwGif; aumif;rGef vHkavmufaom jyKpkukorIrsm; &rnfqdkvSsif ESpfq,fhav;em&D ausmfvSsif touftEÅ&m,ftwGuf rpdk;&drf&aomfvnf; ? ESpfq,fav;em&D twGif;ürl tvGeftrif; 0rf;avSsmrIaMumifh a&"gwfqHk;½HI;um touftEÅ&m,f &SdEdkifayonf/
xdkYaMumifh tqdyfoifhaomoltm; eD;pyf&m aq;½kH? aq;cef;odkY tvsiftjrefydkY&ef vdktyfayonf/ aq;½Hkaq;cef;ESifh a0;vHvSaom ae&mrsm;wGifrl a&S;OD;olemjyKpkenf;rsm;taejzifh tpmtdrfwGif;rS Muufqlaphrsm;udk jyefxGufapjcif;tvdkYiSm tqdyfoifholtm; tefap&efjyKvkyfay;jcif;? a&"gwf rqHk;½IH;ap&ef "gwfqm;&nf wdkufjcif;rsm;udk jyKvkyfay;edkifygonf/
Muufqlaphyifonf wESpfwGif ESpfoD;oD;aom tyifjzpfjyD; toD;pGwfcsdefrSm arvESifh edk0ifbmvrsm; jzpfonf/ aEGoD;onf wyifvSsif EdkYqDAl; wpfAl;cefYom&&SdNyD; rdk;oD;onf wyifvSsif wpfjynfcefY xGuf&Sdedkifayonf/ ,ckESpf aEG&moD toD;oD;aom tcsdefwGifyif uav;i,frsm; tqdyfoifhaom yrmPrSm wdk;yGm;vsuff &SdaeaomaMumifh rdk;aESmif;umv toD;rsm;aom tcsdefrsm;twGuf pdk;&drfzG,f&myif jzpfonf/
xdkYaMumifh NcHpnf;½dk;Muufql;½dkif;yifonf vlom;wdkYtm; vGefpGm tusKd;&Sdaumif; &Sdrnfjzpfaomfvnf; tcefYroifhí pm;oHk;rdaomtcgü touftEÅ&m,f &SdedifaomaMumifh vltrsm; oGm;vmwwfaom ae&m? uav;oli,frsm; tvG,fwul a&mufEdkifaom ae&mrsm;wGif pdkufyskKd;jcif;rS a&SmifusOfjcif;? rdcifESifh uav;i,frsm;tm; NcHpnf;&dk; Muufqlyif½dkif;\ qdk;usKd;ESifh &v'frsm;udk &Sif;jyjcif;tm;jzifh ¤if;rS jzpfay:wwfaom aemufqufwJG tqdyfoifhrI ab;'PfrS umuG,fEdkifrnf jzpfaMumif; today;tyfygonf/
rGef;oufyef (aq;- 1)
------------------------------
&efukefNrdKUwifrubJ jrefrmjynf wpfjynfvHk;u jynfolawGtm;vHk; txl;ojzifh uav;oli,fawG Muufqlyifu xGufvmwJh tqdyfeJUqufpyfNyD; usef;rma&; todynm &apcsifvdkU rrGef;oufyef\ bavmhcfrS wqifh ul;,lazmfjyygw,f/ uav;awG&JU taumif;qHk; tusdK;pD;yGg;udk arQmfrSef;NyD; 'Dusef;rma&;todudk wwfEdkifoavmuf vufqifhurf; qufvuf jzefUa0ay;ygcifAsm vdkU wdkufwGef;EId;aqmfvdkufygw,f/
þ&mpk ESpfydkif;wGif &efukefNrdKYwGif;&Sd tqdyfoifh vlem vufcH&m Xmersm;odkY enf;rsKd;pHkjzifh tqdyf oifhcH&aom vlemrsm; tcsdeftcg ra&G;a&muf&Sd vmwwfMuNyD; ¤if;wdkY\ ta&twGuf rSmvnf; waeYwjcm; wdk;yGm;vsuf &Sdonfudk awGY&avonf/ taBumif; trsdK;rsdK;aBumifY tqdyfoifYí a&muf&SdvmBuaom vlemrsm;rSm trsm;tm;jzifY vlrIa&;? pD;yGm;a&;? ynma&; tqifrajy jzpfaomaBumifY pdwfnpfí vkyfrdvkyf&mudk jyKrd&mrS a&muf&SdvmBujcif;jzpfonf/ ¤if;wdkY oHk;pGJaom ypönf;rsm;rSmvnf; acsmif;qdk; aysmufaq;? tdyfaq;? ESvHk;aq;? tzsm;aysmufaq;ponfY aq;0g;rsm;rSpí a&eHqD? "gwfqD? t&ufysH? aBuG*sD;cGßwfaq;? ydkvdk*sydk;owfaq; txd &SdBuavonf/
tqdyfoifh olrsm;\ wlnDaomtcsufum; w'*FtwGif;jzpfay:aom pdwfzdpD;rIudk rcHedkifí aomufoHk;rdBujcif; jzpfonf/
,ckESpfrsm;wGifrl wrlxl;jcm;pGmjzifY a&muf&SdvmBuaom tqdyfoifUvlemrsm;rSm uav;i,frsm; jzpfBujyD; ¤if;wdkYrSm pdwfnpfí tqdyfoifYvlem jzpf&jcif;rsKd;r[kwfay/ uav;i,frsm; twwfprf;um pm;oHk;Buaom t&mrSm jcHpnf;&dk; Buufqlyif½dkif;[k vltrsm;odBuaom tyifrS&aom Buufqlaph jzpfonf/ Muufqludk jrefrmtbd"mef tusOf;csKyf twJG (1) pmrsufESm (60) wGif taphrS&aom qDudk 0rf;EIwfqD tjzpfoHk;&aom vufjcm;&GufBuD;&Sdonfh tyif [kazmfjycJhonf/
Muufql trsdK;aygif; 70 ausmf&Sdonfhteuf Muufqlyif½dkif;\ rsKd;&if;trnfrSm Euphorbiaceae jzpfjyD; &ku©aA'trnfrSm jatropa curcus jzpfonf/
MuufqlyifESifh tyifxGuf ypönf;rsm;udk wcsKdYaom tmz&du taemufydkif; a'orsm;wGif 0rf;EIwfaq;? oHcsaq; tjzpfvnfaumif;? arG;zGm;& vG,fulap&ef vnf;aumif;? om;avsmapjcif; tvdkYiSm vnf;aumif;? a&zsif;pJGa&m*g? a*gufa&m*g? wcsKdYaom ta&jym; a&m*grsm;udk uko&ef vnf;aumif; oHk;pJGonfudk awGU&onf/
NcHpnf;½dk; Muufql½dkif; tapYudk Budwfí&aomqDudk v,f,mvkyfief;oHk; vufwGef; xGefpufESifh a&pkyfpuf? 'DZ,ftif*sifrsm;wGif jyefvnfjyKjyif&ef rvdkyJ wdkuf&dkufxnfhoGif; toHk;jyKedkifonf/
jrefrmEdkifiH tESHtjym;wGif Buufqlyif&dkif;rsm;udk vGefcJYaomwpfESpfcefYu pwif pdkufysdK;cJYaomfvnf; Buufqlyifonf 6 vrS 8 vwGif pwifí toD;poD;ekdifaomtyif jzpfav&m ,ckvdk aEG&moD ausmif;tm;&ufwGif &yfuGufwdkif;&Sd BuufqlyifwdkYü toD;rsm; a0a0qmqm jzpfaeBujcif; jzpfonf/
BuufqloD; wvHk;wGif tapY 3 apY yg0ifonf/ tapY wapYpDudk tcHGyg; teufa&mif? tndka&mif uav;rsm;jzifY tkyfxm;jyD; twGif;ü tjzLa&mif&SdonfY BuufqlapY twGif;om; &Sdonf/ ¤if;tjzLa&mif twGif;om;\ t&omrSm Am'HapY? oD[dkapYwdkYuJYodkY uGßwfqwfí qdrfYaomaBumifY uav;rsm; prf;oyf pm;oHk;rdBujcif;? BudKufESpfoufí xyfrHpm;oHk;rdjcif; jzpfonf/
trSefppfppfwGif BuufqlapYwGifyg0ifaom "gwfwrsKd;onf qdkuf&mEdkuf tqdyfxuf tqaygif; 6000? cavmuf ajrGqdyfxuf tqaygif; 10000? ydkrdkjyif;xefjyD; obm0 twdkif; awGY&Sdedkifaom tqdyfwrsdK; jzpfonf/
BuufqlwGif t"dutm;jzifY tqdyfjzpfapaomt&m ESpfrsdK;yg0ifonf/ wrsdK;rSm &Dpif (ricin) jzpfjyD; aemufwrsdK;rSm RCA (Ricinus communis agglutinin) jzpfonf/ odkYaomf BuufqlapYudk pm;oHk;jcif;rS &&Sdaom tqdyfoifY vu©Pmrsm;onf &Dqif\ tmedoifaBumifYom jzpfavonf/
xkdodkYjzpf&jcif;rSm RCA udk tleH&Hrsm;rS rpkyf,ledkifaomaBumifY jzpfonf/ tu,fírsm; RCA udk aoG;aBumxJodkY wdkuf½dkufxdk;oGif;rdygrl ¤if;onf aoG;eDOrsm;pGmudk aygufuJGapjcif;jzifh vlom;wdkYtm; tEÅ&m,fjyKEdkifayonf/ tqdyfoifYcH&aom uav;i,fonf BuufqlapY\ tjyifvTm trJudkcGmjyD; twGif;om;udk 0g;pm;rdaomtcsdefü Ricin tmedoifrsm; pwifjzpfay:apNyD;? tqdkyg Ricin onf cE¨mudk,fwGif;&SdqJvf (cells) rsm;udk tqdyfoifh apaomaMumifhjzpfonf/
NcHpnf;½dk;Muufql½dkif;\ taphjzpfaom MuufqlaphwGifyg0ifaom y&dkwdef; (protein) wrsKd;jzpfonfh umpif (carcin) onfvnf; &Dpif (Ricin) uJhodkYyif tpGrf; tmedoif&SdNyD; jyif;tm; tenf;i,f avsmhavonf/
Muufqlaphudk pm;oHk;rdaom olonf pm;jyD;em&D0ufrS 1 em&DtwGif; vnfacsmif; yljcif;? Adkuf&pfemjcif; rsm;cHpm;&NyD; xdkYaemufrl;jcif;? tefjcif;? 0rf;oGm;jcif;rsm; jzpfekdifygonf/ pm;oHk;aom yrmPrsm;onfESifh trSs aoG;0rf;oGm;jcif;? aoG;tefjcif;? a&"gwf tvGeftrif; qHk;½IH;jcif;\ vu©Pmrsm;jzpfaom aoG;aygifusjcif;? ESvHk;ckefjrefjcif;? a&iwfjcif;? tmacgifajcmufjcif;? qD;enf;jcif; odkYr[kwf qD;rxGufedkifawmhjcif;? rsufwGif; csKdifh0ifjcif;? uav;i,frsm;wGif ta&jym;\ elasticity avsmh&JoGm;jcif; wdkYudk awGY&wwfonf/
xdkYtjyifacGß;xGufjcif;? rsufqHusOf;jcif;? touf½Ijrefjcif;? Ekef;jcif;? MuGufwufjcif;ESifh yifrtm½HkaMum pepf tm;enf;jcif;wdkY jzpfwwfayonf/
umpif (carcin) onfvnf; cE¨mukd,fwGif;&Sd aoG;eDOrsm;udk aygufuJG apaomaMumifh rsufvHk;wGif; aoG;,dkpdrfhjcif;? aoG;0rf;oGm;jcif;? aoG;tefjcif;? tonf;ESihf ausmufuyfudk xdcdkufapjcif; wdkYudkyg jzpfapwwfonf/ NcHpnf;&dk; Muufqlyif&dkif;\ yifpnf? t&Guf? toD;wdkYwGifvnf; tvm;wl tmedoifrsm; &SdaMumif; awGY&Sd&ao;onf/
tqdyfoifhaom olonf tcsdefwdktwGif; aumif;rGef vHkavmufaom jyKpkukorIrsm; &rnfqdkvSsif ESpfq,fhav;em&D ausmfvSsif touftEÅ&m,ftwGuf rpdk;&drf&aomfvnf; ? ESpfq,fav;em&D twGif;ürl tvGeftrif; 0rf;avSsmrIaMumifh a&"gwfqHk;½HI;um touftEÅ&m,f &SdEdkifayonf/
xdkYaMumifh tqdyfoifhaomoltm; eD;pyf&m aq;½kH? aq;cef;odkY tvsiftjrefydkY&ef vdktyfayonf/ aq;½Hkaq;cef;ESifh a0;vHvSaom ae&mrsm;wGifrl a&S;OD;olemjyKpkenf;rsm;taejzifh tpmtdrfwGif;rS Muufqlaphrsm;udk jyefxGufapjcif;tvdkYiSm tqdyfoifholtm; tefap&efjyKvkyfay;jcif;? a&"gwf rqHk;½IH;ap&ef "gwfqm;&nf wdkufjcif;rsm;udk jyKvkyfay;edkifygonf/
Muufqlaphyifonf wESpfwGif ESpfoD;oD;aom tyifjzpfjyD; toD;pGwfcsdefrSm arvESifh edk0ifbmvrsm; jzpfonf/ aEGoD;onf wyifvSsif EdkYqDAl; wpfAl;cefYom&&SdNyD; rdk;oD;onf wyifvSsif wpfjynfcefY xGuf&Sdedkifayonf/ ,ckESpf aEG&moD toD;oD;aom tcsdefwGifyif uav;i,frsm; tqdyfoifhaom yrmPrSm wdk;yGm;vsuff &SdaeaomaMumifh rdk;aESmif;umv toD;rsm;aom tcsdefrsm;twGuf pdk;&drfzG,f&myif jzpfonf/
xdkYaMumifh NcHpnf;½dk;Muufql;½dkif;yifonf vlom;wdkYtm; vGefpGm tusKd;&Sdaumif; &Sdrnfjzpfaomfvnf; tcefYroifhí pm;oHk;rdaomtcgü touftEÅ&m,f &SdedifaomaMumifh vltrsm; oGm;vmwwfaom ae&m? uav;oli,frsm; tvG,fwul a&mufEdkifaom ae&mrsm;wGif pdkufyskKd;jcif;rS a&SmifusOfjcif;? rdcifESifh uav;i,frsm;tm; NcHpnf;&dk; Muufqlyif½dkif;\ qdk;usKd;ESifh &v'frsm;udk &Sif;jyjcif;tm;jzifh ¤if;rS jzpfay:wwfaom aemufqufwJG tqdyfoifhrI ab;'PfrS umuG,fEdkifrnf jzpfaMumif; today;tyfygonf/
rGef;oufyef (aq;- 1)
------------------------------
&efukefNrdKUwifrubJ jrefrmjynf wpfjynfvHk;u jynfolawGtm;vHk; txl;ojzifh uav;oli,fawG Muufqlyifu xGufvmwJh tqdyfeJUqufpyfNyD; usef;rma&; todynm &apcsifvdkU rrGef;oufyef\ bavmhcfrS wqifh ul;,lazmfjyygw,f/ uav;awG&JU taumif;qHk; tusdK;pD;yGg;udk arQmfrSef;NyD; 'Dusef;rma&;todudk wwfEdkifoavmuf vufqifhurf; qufvuf jzefUa0ay;ygcifAsm vdkU wdkufwGef;EId;aqmfvdkufygw,f/